Application Of Collagen And Growth Factors For Bone And Nerve Healing Processes Application Of Collagen And Growth Factors For Bone And Nerve Healing Processes
Keywords
Collagen, Growth Factor, Tissue Engineering, Bone Regeneration, Nerve Regeneration, Collagen, Growth Factor, Tissue Engineering, Bone Regeneration, Nerve Regeneration
Abstract
Abstract: Collagen has weak antigenicity, good biocompatibility, biodegradability and biomechanical properties. It is widely used in tissue engineering of skin, tendons, blood vessels, bones and nerves, etc. Growth factors are a kind of trace amounts in the body. A small molecule substance that effectively regulates cell metabolism and tissue repair. Collagen-growth factor biomaterials (CGFB) exhibit excellent biological and biomechanical properties in bone tissue regeneration, nerve tissue repair, tendon reconstruction and chronic wound repair. In bone tissue repair, CGFB rationally releases growth factors, effectively induces osteogenic differentiation of stem cells and promotes the repair of damaged bone tissue. In nerve tissue repair, the specific CGFB collagen design used according to the repair object effectively promotes the generation of neurites. In the repair of the central nervous system, the injection of collagen gel provides a good microenvironment for cell growth, which is beneficial to the repair of the central nervous system. This article reviews the basic properties of CGFB and its research progress in the field of bone and nerve repair in recent years to predict the direction in which it can continue to be improved in the future. Abstract: Collagen possesses weak antigenic activity, high biocompatibility, biodegradability, and biomechanical properties. It has been widely used in tissue engineering of various organs, such as skin, tendons, blood vessels, nerves, and bones. Growth factors are a class of molecules that effectively regulate cell metabolism and tissue repair. Collagengrowth factor biomaterials(CGFB) exhibit desirable biological and biomechanical properties in osteogenesis, nerve repair, tendon reconstruction, and repair of chronic wounds. In the process of osteogenesis, CGFB ideally release growth factors, effectively inducing osteogenic differentiation of stem cells, thus promoting repair in bone defects. In the process of nerve repair, a specific design of CGFB for a purpose can effectively promote neuritis generation. In the process of central nervous system repair, the injection of collagen gel can provide a desirable microenvironment for cells, which is beneficial for central nervous system repair. This article reviews the basic properties and recent studies in bone and nerve repair of CGFB to provide future direction of improvement
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Original research was done by Zhu Chenyou, Cao Yubin, Deng Jia, Qi Wenting, Cao Cong, Shi Bing
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