Early Animal In Vivo Implantation Experimental Study Of New Gbr Collagen Membraneguided Bone Regeneration In Mandibular Defects Using A Novel Collagen Membrane.
Keywords
Collagen Membrane, Guided Bone Regeneration (Gbr), New Bone Formation
Abstract
Abstract Purpose: To explore the ability of the new domestic GBR collagen membrane to induce early submembranous osteogenesis after implantation in vivo. Methods: The experiment was completed at the Animal Experiment Center of Shenyang Military Region General Hospital from October 2013 to March 2014. Miniature Bama pigs were selected, and three 8mm ¡Á 8mm full-thickness bone defects were prepared using dental fissure drills on both sides of the mandibular body. The experimental collagen membrane, Bio-gide@, and non-covering membrane were used to cover the bone defects respectively. The animals were sacrificed 1 month after surgery, and tetracycline solution and xylenol orange solution were injected intramuscularly 1 and 2 weeks before sacrifice. After fixing the samples, prepare hard tissue sections. The degradation degree of the membrane and the new bone formation capacity under the membrane were observed under a fluorescence microscope and an optical microscope (toluidine blue, methylene blue-acid fuchsin staining), and the amount of submembranous bone formation and bone maturity of the material were evaluated. Results: The collagen membrane of the experimental group had a good barrier effect, and the degree of new bone mineralization under the membrane was good; the bone trabeculae were arranged neatly, but the amount of new bone was less than that of the control group. Conclusion: The new domestic collagen membrane has no obvious degradation at 1 month and has good submembranous bone formation ability. The collagen membrane of the experimental group needs to be modified to increase the amount of submembranous bone formation.
For further information of this article and research, feel free to contact our team for asssitance.
Original research was done by Bai Bing, Zhu Jingtao, Feng Lifang, Song Rongbo, BAI Bing, ZHU Jing-tao, FENG Li-fang, et al.
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.
