Effects Of Fengshi Bitong Recipe On Serum Cytokines And Fas/Fasl Mrna Expression In Synovial Tissue In Rats With Collagen-Induced Arthritis
Keywords
Fengshi Bitong Recipe, Collagen-Induced Arthritis, Inflammatory Factors, Apoptosis, Rats
Abstract
Objective To observe the effect of Fengshi Bitong Recipe on serum cytokines and Fas/FasL mRNA expression in synovial tissue of rats with collagen-induced arthritis (CIA), and explore its related mechanism of action. Methods The CIA model was established by intradermal injection of bovine type II collagen emulsifier into the feet of rats. Experimental rats were randomly divided into blank group, model group, Tripterygium wilfordii polyglycoside group and Fengshi Bitong Recipe low, medium and high dose groups. Each administration group was given corresponding drugs by gavage for 14 consecutive days. The body weight and arthritis scores of rats in each group were observed; serum interleukin (IL)-1¦Â, IL-15, and transforming growth factor (TGF)-¦Â1 contents were detected by ELISA; Fas and FasL mRNA in synovial tissue were detected by RT-PCR. Express. Results Compared with the model group, the foot arthritis score and serum IL-15 content of rats in the medium and high-dose Fengshi Bitong Recipe groups were significantly reduced, and the TGF-¦Â1 content was significantly increased (P<0.01). The expression of Fas mRNA in the group was significantly reduced, and the expression of FasL mRNA was significantly increased (P<0.05). Conclusion Fengshi Bitong Recipe has a certain immunoregulatory effect on CIA, and its mechanism may be through regulating the Fas/FasL apoptosis system, inducing synovial tissue cell apoptosis and inhibiting synovial hyperplasia. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by 10.3969/j.issn.1005-5304.2017.12.013
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