Expression And Significance Of Mmp-2 And Mmp-9 In Breast Ductal Carcinoma
Keywords
Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Breast Cancer, Type Iv Collagen, Immunohistochemistry
Abstract
Objective To study the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in breast ductal carcinoma and their relationship with type IV collagen (collagenIV). Methods Immunohistochemical double staining method was used to detect the expression of MMP-2, MMP-9 and type IV collagen in 60 cases of breast ductal carcinoma and analyze their correlation with tumor size, lymph node metastasis and human epidermal growth factor receptor-2 (C -erbB-2) relationship. Results The positive expression rates of MMP-2 and MMP-9 in breast ductal carcinoma were 75% and 80% respectively, which were significantly higher than 10% in normal breast tissue; MMP-2 and MMP-9 were close to the basement membrane or would break through the basement membrane. The expression of MMP-2 and MMP-9 was significantly enhanced in cancer cells at the membrane. %, 85.1%) expression rate was significantly higher than that of the corresponding control group (58.6%, 65.5%), (64.9%, 67.6%), (46.2%, 53.8%); the expression of type IV collagen was related to MMP-2, MMP- 9 expressions were all negatively correlated. Conclusion In the process of local invasion and distant metastasis of breast ductal carcinoma, MMP-2 and MMP-9 may play an important role in the degradation of type IV collagen. The joint detection of MMP-2, MMP-9 and type IV collagen may play an important role in the judgment of breast ductal carcinoma. It has reference value for the invasive and metastatic potential of breast cancer and for assessing prognosis.
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Original research was done by Su Shujuan, Xing Luqi, Chen Dengting, Deng Miao
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