Pig Skin Collagen Peptide Chelated Calcium Increases Bone Density In Rats
Keywords
Pig Skin Gelatin, Polypeptide Chelated Calcium, Sd Rats, Bone Density
Abstract
Using pig skin collagen polypeptide (CP) and calcium gluconate prepared in the laboratory as raw materials, a liquid reaction method was used to synthesize calcium-binding CP (CP-Ca), and the increase in SD of CP-Ca was evaluated. Effect on bone mineral density (BMD) in rats. 120 weaned female 4-week-old SD rats were randomly divided into 10 groups: 1) control group (gavage with deionized water); 2) low, medium and high dose CP-Ca groups (139.28, 278.55, 557.10 mg/ (100 g¡¤d)); 3) Low, medium and high dose CaCO3 groups (25, 50, 100 mg/(100 g¡¤d)); 4) Low, medium and high dose CP+CaCO3 groups (139.28 mg/(100 g¡¤d) CP+25 mg/(100 g¡¤d) CaCO3, 278.55 mg/(100 g¡¤d) CP+ 50 mg/(100 g¡¤d) CaCO3, 557.10 mg/(100 g¡¤d) CP+100 mg/(100 g¡¤d)CaCO3). All experimental rats were fed basic diet and drank deionized water ad libitum. During the experiment, the body weight and length of the rats were measured every week, and a 3-day calcium metabolism experiment was performed on the 4th week after intragastric administration. Rat serum calcium (S-Ca), serum phosphorus (SP) concentration, alkaline phosphatase (ALP) activity, rat BMD and bone calcium content were measured, and the rat femurs were scanned using scanning electron microscopy (scanning electron microscopy). microscope, SEM) analysis. The results showed that the medium and high-dose CP-Ca groups and the high-dose CP+CaCO3 group could significantly promote the increase in body weight and development of rats (P<0.05), and the effect of CP-Ca was more obvious. The ALP activity of the CP-Ca group and CP+CaCO3 group was significantly lower than that of the control group (P<0.05), while the BMD of the medium- and high-dose CP-Ca group and the medium- and high-dose CP+CaCO3 group was significantly higher than that of the control group (P<0.05), and The high-dose CP-Ca group was higher than the corresponding dose CP+CaCO3 group. The apparent calcium absorption rates of each dose CP-Ca group and CP+CaCO3 group were respectively higher than the corresponding CaCO3 group. CP-Ca has the effect of promoting bone growth, development, and bone calcium deposition in rats. effect. SEM results show that CP-Ca and CP+CaCO3 can prevent and improve osteoporosis in rats caused by long-term insufficient calcium intake. CP-Ca has high solubility, good dissociation, and is rich in calcium and peptides. It can prevent osteoporosis and increase bone density. For further information of this article and research, feel free to contact our team for asssitance. Original research was done by Dong Wenbin,Xu Xianmeng
About ETChem
ETChem, a reputable Chinese Collagen factory manufacturer and supplier, is renowned for producing, stocking, exporting, and delivering the highest quality collagens. They include marine collagen, fish collagen, bovine collagen, chicken collagen, type I collagen, type II collagen and type III collagen etc. Their offerings, characterized by a neutral taste, and instant solubility attributes, cater to a diverse range of industries. They serve nutraceutical, pharmaceutical, cosmeceutical, veterinary, as well as food and beverage finished product distributors, traders, and manufacturers across Europe, USA, Canada, Australia, Thailand, Japan, Korea, Brazil, and Chile, among others.
ETChem specialization includes exporting and delivering tailor-made collagen powder and finished collagen nutritional supplements. Their extensive product range covers sectors like Food and Beverage, Sports Nutrition, Weight Management, Dietary Supplements, Health and Wellness Products, ensuring comprehensive solutions to meet all your protein needs.
As a trusted company by leading global food and beverage brands and Fortune 500 companies, ETChem reinforces China’s reputation in the global arena. For more information or to sample their products, please contact them and email karen(at)et-chem.com today.
