Research Progress On The Relationship Between Collagen Post-Translational Modification Enzymes And Tumors
Keywords
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Abstract
Abstract Collagen deposition and hardening can promote tumor progression. The biosynthesis of collagen includes transcription, translation and modification. The post-translational modification of collagen is catalyzed by a variety of enzymes. The stability of the modified collagen is enhanced and the biological function is guaranteed. Studies have shown that the key enzymes for post-translational modification of collagen include prolyl-4-hydroxylase (P4H), lysyl hydroxylase (LH) and lysyl oxidase (LOX). ) is closely related to tumors, and its abnormal expression can cause collagen to remodel and harden, thereby promoting the occurrence, development, invasion and metastasis of tumors. In addition, these enzymes may be potential targets for treating cancer. This article reviews the basic characteristics of these three enzymes and their connection with tumor progression.
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Original research was done by Wei Xiaohui, Sun Li, Yuan Shengtao, Kuang Xinhong
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