Study On The Biological Behavior Of Fibroblasts In Collagen Nodules Of Hypertrophic Scars
Keywords
Hypertrophic Scar Collagen Nodule Fibroblast Myofibroblast Ki67 ¦¡-Sma Hypertrophic Scar Collagen Nodule Fibroblast Myofibroblast Ki67 ¦¡-Sma
Abstract
Objective To study the biological behavior and significance of fibroblasts (Fb) in collagen nodules of hypertrophic scars. Methods The scar tissue removed during scar excision and skin grafting surgery and the remaining normal skin specimens were collected. The histomorphological differences between normal skin and scar tissue collagen nodules and non-nodule areas were observed with HE staining. The immunohistochemistry method was used to detect the differences between normal skin and scar tissue. Expression and distribution of Ki67 and ¦Á-smooth muscle actin (¦Á-SMA). Results Compared with normal skin and non-collagen nodule areas of hypertrophic scars, a large number of Fb could be seen in collagen nodules of hypertrophic scars. Fb with positive expression of Ki67 and ¦Á-SMA were also mainly distributed in the collagen nodule area. Conclusion Fb proliferate actively in collagen nodules and differentiate into myofibroblasts (MFB) in large numbers. The presence of a large amount of MFB indicates that the local tissue is at a high tension level, which may be one of the important mechanisms leading to active Fb function and the large presence of MFB to form collagen nodules. Objective To investigate the biological behavior of fibroblasts (Fbs) in collagen nodules of hypertrophic scar. Methods Scar and normal skin specimens were collected from patients with scar excision and skin grafting operation. The histological differences between normal skin and collagen nodules and non-nodular area were observed by light microscopy with HE staining. The expression and distribution of Ki67 and alpha-smooth muscle actin (¦Á-SMA) in normal skin and scar tissue were detected by immunohistochemical analysis. Results Compared with the normal skin and non-nodular area in hypertrophic scar, collagen nodules showed a large amount of Fb, and the positive expression of Ki67 and ¦Á-SMA was distributed mainly in Fbs located in collagen nodules. ConclusionFibroblasts in collagen nodules are proliferated actively, and differentiated to myofibroblasts, leading to the high tension of local tissue, which may be an important mechanism of collagen nodules formation
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Original research was done by Lin Weidong, Liu Weiwei, Jiang Wanli, Qian Xiong, Song Fei, Liu Yingkai
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